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Serum levels of cathepsin K decrease with age in both women and men.

K Kerschan-Schindl·G Hawa·S Kudlacek·W Woloszczuk·P Pietschmann
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Abstract

Bone turnover increases with age. In a previous study, we reported on bone metabolism in young and elderly women and men. The aim of the present investigation was to evaluate potential age- and gender-related changes in cathepsin K, a cysteine protease that plays an important role in the degradation of the organic matrix of bone. Twenty-five healthy premenopausal women, 24 young healthy men, 26 elderly women, and 25 elderly men participated in the study. Elderly women and men had significantly lower cathepsin K levels than younger ones. In both men and women, serum levels of cathepsin K were negatively correlated with age. In men there was a statistically significant negative correlation between serum levels of cathepsin K and osteoprotegerin, which inhibits osteoclast differentiation and activation. No association was found between serum levels of cathepsin K and bone-specific alkaline phosphatase, osteocalcin, or 25-hydroxy vitamin D. Thus, the age-related increase in OPG, which markedly inhibits the expression of cathepsin K, may also reduce serum levels of cathepsin K. Despite the age-related increase in bone resorption, this study shows lower cathepsin K values in elderly women and men than in younger subjects. It might be speculated that a different enzyme could compensate for the decline in cathepsin K during old age.

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AdultAged, 80 and overAgingAlkaline PhosphataseBone ResorptionBone and BonesCathepsin KCathepsinsCysteine EndopeptidasesFemaleGlycoproteinsHumansMaleOsteocalcinOsteoprotegerinReceptors, Cytoplasmic and NuclearReceptors, Tumor Necrosis FactorSex FactorsVitamin DJournal Article

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K Kerschan-Schindl, G Hawa, S Kudlacek, W Woloszczuk, P Pietschmann. 2005. Serum levels of cathepsin K decrease with age in both women and men.. https://doi.org/10.1016/j.exger.2005.04.001

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