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Pathways to caspase activation.

Zi-Bing Wang·Yu-Qing Liu·Yu-Fang Cui
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Abstract

Apoptosis or programmed cell death is an active form of cell death which is essential for tissue homeostasis. Many proteins are involved in the molecular signal transduction of apoptosis. The caspase enzymes, a family of specific cysteine proteases, play a central role in cell death machinery. In this review, we mainly discuss the current understanding of several pathways to activate caspases and some key proteins related to these pathways.

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AnimalsApoptosisApoptotic Protease-Activating Factor 1CaspasesCytochromes cEndoplasmic ReticulumEnzyme ActivationGranzymesHumansIntracellular Signaling Peptides and ProteinsMitochondriaPoly(ADP-ribose) PolymerasesProteinsReceptors, Tumor Necrosis FactorSerine EndopeptidasesSignal TransductionJournal ArticleReview

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Zi-Bing Wang, Yu-Qing Liu, Yu-Fang Cui. 2005. Pathways to caspase activation.. https://doi.org/10.1016/j.cellbi.2005.04.001

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