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PubMed · 1594690

FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats.

N Orthen-Gambill·M Salomon
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Abstract

The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period. Hypothalamic H assays, performed at the end of the study, confirmed that FMH-treated rats had significantly lower H levels than controls. In general, the results suggest that H activity and feeding are inversely related.

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AnimalsBody WeightEatingHistamineHistidine DecarboxylaseHypothalamusMaleMethylhistidinesRatsRats, Inbred StrainsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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N Orthen-Gambill, M Salomon. 1992. FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats.. https://doi.org/10.1016/0031-9384(92)90132-l

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