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PubMed · 15948398

[WT1 peptide-based immunotherapy].

Haruo Sugiyama
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Abstract

The Wilms' tumor gene WT1 is overexpressed in leukemia and various types of solid cancers and its product is a tumor rejection antigen. A phase I clinical trials of WT1 peptide-based cancer immunotherapy were performed with good clinical response but with only skin reaction at the injection sites of WT1 vaccine. Thus, WT1-targeting immunotherapy should be promissing.

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AdenocarcinomaAdultAgedAnemia, Refractory, with Excess of BlastsAnimalsBreast NeoplasmsCancer VaccinesCarcinoma, Squamous CellClinical Trials, Phase I as TopicFemaleHumansImmunotherapyLeukemia, Myeloid, AcuteLung NeoplasmsMaleMiddle AgedMyelodysplastic SyndromesT-Lymphocytes, CytotoxicWT1 ProteinsCase ReportsEnglish AbstractJournal ArticleReview

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Haruo Sugiyama. 2005. [WT1 peptide-based immunotherapy].. https://pubmed.ncbi.nlm.nih.gov/15948398/

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