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Interleukin-18 does not modulate the acute-phase response.

Rogier J L Stuyt·Mihai G Netea·Ineke Verschueren·Charles A Dinarello·Bart Jan Kullberg·Jos W M van der Meer
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Abstract

IL-18 is a pro-inflammatory cytokine of the IL-1 family and it induces IL-1, TNF, and IL-6, all of which are endogenous pyrogens. The pyrogenic properties of recombinant IL-18 were studied in a rabbit model of fever. rIL-18 did not cause fever when injected intravenously into rabbits. Furthermore, the ability of rIL-18 to modulate other components of the acute-phase response was assessed. rIL-18 did not induce leukocytosis, or changes of circulating concentrations of lipoproteins and corticosterone in mice. In conclusion, rIL-18 is not able to induce a febrile response in rabbits and does not modulate the acute-phase response in mice.

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Acute-Phase ReactionAnimalsBody TemperatureCholesterolCorticosteroneFeverGlucocorticoidsHumansInterleukin-18Leukocyte CountLeukocytosisLipidsMiceMice, Inbred C57BLRabbitsRecombinant ProteinsTriglyceridesJournal Article

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Rogier J L Stuyt, Mihai G Netea, Ineke Verschueren, Charles A Dinarello, Bart Jan Kullberg, Jos W M van der Meer. 2005. Interleukin-18 does not modulate the acute-phase response.. https://doi.org/10.1179/096805105x35170

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