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Levels of complexity in pathogen recognition by C-type lectins.

Alessandra Cambi·Carl G Figdor
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Abstract

In pathogen recognition by C-type lectins, several levels of complexity can be distinguished; these might modulate the immune response in different ways. Firstly, the pathogen-associated molecular pattern repertoire expressed at the microbial surface determines the interactions with specific receptors. Secondly, each immune cell type possesses a specific set of pathogen-recognition receptors. Thirdly, changes in the cell-surface distribution of C-type lectins regulate carbohydrate binding by modulating receptor affinity for different ligands. Crosstalk between these receptors results in a network of multimolecular complexes, adding a further level of complexity in pathogen recognition.

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AnimalsAntigensCarbohydrate MetabolismCarbohydratesHumansLectins, C-TypeJournal ArticleReview

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Alessandra Cambi, Carl G Figdor. 2005. Levels of complexity in pathogen recognition by C-type lectins.. https://doi.org/10.1016/j.coi.2005.05.011

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