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PubMed · 15951049

Shaping time: chromatin structure and the DNA replication programme.

Anne D Donaldson
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Abstract

DNA is replicated according to a precise and reproducible temporal pattern. The S-phase programme has previously been analyzed in metazoan and yeast cells using different methods: cytological chromosome banding in human cells and DNA isotopic-labeling techniques in yeast. Microarray-based approaches for the analysis of the replication programme and chromatin structure are bringing us closer to a molecular understanding of the factors that determine replication time. In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans.

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AnimalsChromatinDNA ReplicationDNA, FungalGenome, FungalGenome, HumanHumansKineticsOligonucleotide Array Sequence AnalysisSaccharomyces cerevisiaeSpecies SpecificityComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Anne D Donaldson. 2005. Shaping time: chromatin structure and the DNA replication programme.. https://doi.org/10.1016/j.tig.2005.05.012

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