DNA mismatch repair.

Thomas A Kunkel; Dorothy A Erie

doi:10.1146/annurev.biochem.74.082803.133243

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DNA mismatch repair.

Thomas A Kunkel·Dorothy A Erie

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Abstract

DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functions of MMR proteins and the consequences of impaired function. We then focus on the biochemical mechanism of MMR replication errors. Emphasis is on structure-function studies of MMR proteins, on how mismatches are recognized, on the process by which the newly replicated strand is identified, and on excision of the replication error.

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Adenosine Triphosphatases Bacterial Proteins Base Pair Mismatch DNA Repair DNA Repair Enzymes DNA-Binding Proteins Escherichia coli Escherichia coli Proteins Eukaryotic Cells Humans Models, Biological Models, Molecular Multiprotein Complexes MutS DNA Mismatch-Binding Protein Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Thomas A Kunkel, Dorothy A Erie. 2005. DNA mismatch repair.. https://doi.org/10.1146/annurev.biochem.74.082803.133243

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