Association between hematological parameters and high-density lipoprotein cholesterol.

Patrick M Moriarty; Cheryl A Gibson

doi:10.1097/01.hco.0000167722.22453.47

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PubMed · 15956830

Association between hematological parameters and high-density lipoprotein cholesterol.

Patrick M Moriarty·Cheryl A Gibson

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Abstract

PURPOSE OF REVIEW: The ability of high-density lipoprotein cholesterol to reverse atherosclerosis and reduce cardiovascular disease has been shown in several randomized controlled trials. One mechanism by which high-density lipoprotein cholesterol protects the vascular system includes hemorheology, the study of blood flow. RECENT FINDINGS: Blood viscosity, or the resistance of flow, can be altered by red blood cell aggregation, red blood cell deformability, and plasma viscosity. Elevated high-density lipoprotein cholesterol levels may improve all of these rheological mediators. An infusion of recombinant high-density lipoprotein cholesterol can immediately release nitric oxide, a potent vasodilator and responder to changes in rheology, into the arteries by activation of endothelial nitric oxide synthase. The stimulation of nitric oxide release by high-density lipoprotein cholesterol may also alter blood rheology. SUMMARY: In this article, we will review hemorheology, particularly blood viscosity along with other hemorheological factors, and examine their association with high-density lipoprotein cholesterol.

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Atherosclerosis Blood Viscosity Cardiovascular Diseases Cholesterol, HDL Erythrocyte Aggregation Erythrocyte Deformability Hemorheology Humans Journal Article Review

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Patrick M Moriarty, Cheryl A Gibson. 2005. Association between hematological parameters and high-density lipoprotein cholesterol.. https://doi.org/10.1097/01.hco.0000167722.22453.47

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