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Immortalized human microglial cell line: phenotypic expression.

Atsushi Nagai·Seiji Mishima·Yuri Ishida·Hiroto Ishikura·Takayuki Harada·Shotai Kobayashi·Seung U Kim
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Abstract

Microglia are a major neuroglial component of the CNS, playing an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. To understand the role of microglia in the CNS in health and diseases, we have recently established an immortalized clonal cell line of human microglia, HMO6, from human embryonic telencephalon tissue by using a retroviral vector encoding v-myc. This immortalized microglia HMO6 cell line exhibits cell-type-specific antigens for microglia, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin, and actively phagocytoses latex beads.

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AnimalsAntigen-Presenting CellsCell LineCell TransplantationChemokinesCytokinesGene Expression RegulationHumansMiceMicrogliaPhenotypeJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Atsushi Nagai, Seiji Mishima, Yuri Ishida, Hiroto Ishikura, Takayuki Harada, Shotai Kobayashi, Seung U Kim. 2005-08-01. Immortalized human microglial cell line: phenotypic expression.. https://doi.org/10.1002/jnr.20478

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