Aging and T cell development: interplay between progenitors and their environment.

Valerie P Zediak; Avinash Bhandoola

doi:10.1016/j.smim.2005.05.004

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Aging and T cell development: interplay between progenitors and their environment.

Valerie P Zediak·Avinash Bhandoola

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Abstract

Thymic involution is the hallmark of hematopoietic aging. Because T cell differentiation is a multistep process that occurs non-cell autonomously, aging defects can occur at multiple points along the developmental pathway, both in the T progenitors themselves and in the thymic stromal cells that support their development. Here we review the evidence for age-related thymopoiesis defects at key steps in the production of naïve mature T cells, highlighting the importance of the interaction between stromal aging and progenitor aging.

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Aging Animals Cell Communication Cell Differentiation Cellular Senescence Hematopoietic Stem Cells Humans T-Lymphocyte Subsets Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Valerie P Zediak, Avinash Bhandoola. 2005. Aging and T cell development: interplay between progenitors and their environment.. https://doi.org/10.1016/j.smim.2005.05.004

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