Reevaluating current models of thymic involution.

Encarnacion Montecino-Rodriquez; Hyeyoung Min; Kenneth Dorshkind

doi:10.1016/j.smim.2005.05.006

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Reevaluating current models of thymic involution.

Encarnacion Montecino-Rodriquez·Hyeyoung Min·Kenneth Dorshkind

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Abstract

It is generally accepted that thymic involution commences, or at least accelerates, at puberty due to increases in sex steroid and declines in growth hormone production. As a result of these hormonal changes, the development of the most immature intrathymic progenitors is blocked. However, aspects of this model are now being questioned. The present chapter re-evaluates a number of findings on which traditional models of thymic involution are based and reviews new data that, taken together, indicate a need to revise current views of thymic involution.

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Aging Animals Humans Models, Immunological T-Lymphocytes Thymus Gland Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.Review

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Encarnacion Montecino-Rodriquez, Hyeyoung Min, Kenneth Dorshkind. 2005. Reevaluating current models of thymic involution.. https://doi.org/10.1016/j.smim.2005.05.006

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