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The HERC proteins: functional and evolutionary insights.

F R Garcia-Gonzalo·J L Rosa
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Abstract

HERC proteins are defined as containing both HECT and RCC1-like domains in their amino acid sequences. Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions. It is now almost 10 years since the discovery of the first family member and information is starting to accumulate pointing to a general role for these proteins as ubiquitin ligases involved in membrane-trafficking events. In this review, the available data on these six members are discussed, together with an account of their evolution.

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Evolution, MolecularHumansModels, MolecularPhylogenyProtein Structure, TertiaryUbiquitin-Protein LigasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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F R Garcia-Gonzalo, J L Rosa. 2005. The HERC proteins: functional and evolutionary insights.. https://doi.org/10.1007/s00018-005-5119-y

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