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Mx scripts library: structural equation modeling scripts for twin and family data.

D Posthuma·D I Boomsma
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Abstract

Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library (http://www.psy.vu.nl/mxbib) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives.

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DNAGenetic MarkersHumansInheritance PatternsLongitudinal StudiesModels, StatisticalMultivariate AnalysisSex FactorsSoftwareTwin Studies as TopicJournal ArticleResearch Support, Non-U.S. Gov't

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D Posthuma, D I Boomsma. 2005. Mx scripts library: structural equation modeling scripts for twin and family data.. https://doi.org/10.1007/s10519-005-2791-5

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