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PubMed · 159725

[Quantitative model of human erythrocyte glycolysis. Region of cell viability determined by ATP concentration].

F I Ataullakhanov·V M Vitvitskiĭ·A M Zhabotinskiĭ·A V Pichugin·B N Kholodenko
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Abstract

The boundaries of the cell vitality domain in the enzyme activity space are calculated on the basis of a mathematical model of erythrocyte glycolysis. The boundaries are determined by key metabolite concentrations. The results obtained are compared with experimental data related to erythrocytic enzymopathies. It is shown that theoretical boundary enzyme activities coincide with the activities of hexokinase and in some cases phosphofruktokinase in enzyme deficient erythrocytes.

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Adenosine TriphosphatasesAdenosine TriphosphateAnemia, HemolyticAnemia, Hemolytic, Congenital NonspherocyticAntineoplastic AgentsErythrocytesGlucose-6-Phosphate IsomeraseGlycolysisHexokinaseHumansMathematicsModels, BiologicalPhosphofructokinase-1Comparative StudyEnglish AbstractJournal Article

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F I Ataullakhanov, V M Vitvitskiĭ, A M Zhabotinskiĭ, A V Pichugin, B N Kholodenko. [Quantitative model of human erythrocyte glycolysis. Region of cell viability determined by ATP concentration].. https://pubmed.ncbi.nlm.nih.gov/159725/

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