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Combining microarrays and genetic analysis.

Rudi Alberts·Jingyuan Fu·Morris A Swertz·L Alrik Lubbers·Casper J Albers·Ritsert C Jansen
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Abstract

Gene expression can be studied at a genome-wide scale with the aid of modern microarray technologies. Expression profiling of tens to hundreds of individuals in a genetic population can reveal the consequences of genetic variation. In this paper it is argued that the design and analysis of such a study is not a matter of simply applying the existing and more-or-less standard computational tools for microarrays to a new type of experimental data. It is shown how to fully exploit the power of genetics through optimal experimental design and analysis for two major microarray technologies, cDNA two-colour arrays and Affymetrix short oligonucleotide arrays.

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Chromosome MappingComputer SimulationGene Expression ProfilingGenomicsModels, GeneticOligonucleotide Array Sequence AnalysisQuantitative Trait LociJournal Article

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Rudi Alberts, Jingyuan Fu, Morris A Swertz, L Alrik Lubbers, Casper J Albers, Ritsert C Jansen. 2005. Combining microarrays and genetic analysis.. https://doi.org/10.1093/bib%2F6.2.135

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