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TMB-Hunt: a web server to screen sequence sets for transmembrane beta-barrel proteins.

Andrew G Garrow·Alison Agnew·David R Westhead
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Abstract

TMB-Hunt is a program that uses a modified k-nearest neighbour (k-NN) algorithm to classify protein sequences as transmembrane beta-barrel (TMB) or non-TMB on the basis of whole sequence amino acid composition. By including differentially weighted amino acids, evolutionary information and by calibrating the scoring, a discrimination accuracy of 92.5% was achieved, as tested using a rigorous cross-validation procedure. The TMB-Hunt web server, available at www.bioinformatics.leeds.ac.uk/betaBarrel, allows screening of up to 10,000 sequences in a single query and provides results and key statistics in a simple colour coded format.

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AlgorithmsEvolution, MolecularInternetMembrane ProteinsProtein Structure, SecondarySequence Analysis, ProteinSoftwareEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

Andrew G Garrow, Alison Agnew, David R Westhead. 2005-07-01. TMB-Hunt: a web server to screen sequence sets for transmembrane beta-barrel proteins.. https://doi.org/10.1093/nar%2Fgki384

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