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Fluorometric assay for N-acetylprocainamide.

E Matusik·T P Gibson
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Abstract

We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective lenear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 +/- 3.0% and 98.0 +/- 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.

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HumansHydrogen-Ion ConcentrationProcainamideSpectrometry, FluorescenceJournal Article

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E Matusik, T P Gibson. 1975. Fluorometric assay for N-acetylprocainamide.. https://pubmed.ncbi.nlm.nih.gov/160/

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