PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 16001265

Multiunit arrector pili muscular structure as a variation observed by using computer-based three-dimensional reconstruction.

Wu-Chul Song·Kyung-Seok Hu·Ki-Seok Koh
View original source ↗Export metadata ↓

Abstract

The arrector pili (AP) muscle was recently suggested to comprise one AP muscular unit inserted into all the hair follicles contained within the follicular unit (FU). This study investigated the presence of variations in AP muscular units associated with the FUs. Human cadaver scalp skin specimens were serially sectioned and stained with Masson's trichrome. Three-dimensional reconstructions of the serially sectioned images were analyzed on a computer, which revealed two types of variation in 20 FUs, one of which was the multiunit AP muscular structure, in which the AP muscular unit was inserted into two or more FUs.

Explore related subjects

Hair FollicleHumansImage Processing, Computer-AssistedModels, AnatomicMuscle, SmoothScalpJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Wu-Chul Song, Kyung-Seok Hu, Ki-Seok Koh. 2005-11-03. Multiunit arrector pili muscular structure as a variation observed by using computer-based three-dimensional reconstruction.. https://doi.org/10.1007/s00441-005-0018-y

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2026

Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.

Hair follicles (HFs) are vital skin appendages that perform fundamental functions including protection, thermoregulation, and sensation. Orchestrated by hair follicle stem cells (HFSCs), HFs undergo cyclic regeneration throughout the lifespan. However, during chronological aging, this mini-organ experiences progressive physiological decline, clinically characterized by a marked reduction in hair density and hair graying due to pigmentation dysfunction. This aging process involves HFSC exhaustion accompanied by diminished regenerative potential and differentiation capacity, leading to degenerative changes in the bulge architecture. Concurrently, the niche supporting HFSC homeostasis undergoes multi-dimensional and systemic degradation. This niche deterioration disrupts the delicate balance between HFSC quiescence and activation, further impeding hair regeneration. In this review, we delineate the dynamic anatomical changes throughout the hair growth cycle and describe the alterations of HFSCs during aging. We specifically focus on the mechanisms underlying the multi-dimensional degradation of the HFSC niche at tissue, cellular, and molecular levels. Furthermore, we discuss various therapeutic strategies aimed at ameliorating HF aging, offering potential insights for future clinical translation in hair regeneration. Finally, we propose that integrating spatiotemporal high-resolution technologies with genomic data to further decipher the spatiotemporal behaviors of aging HFSCs and niche cells will facilitate the establishment of a robust mechanistic framework for HFSC and niche aging.

Hair Follicle↗