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PubMed · 16004080

Retrovirus reverse transcriptases containing a modified YXDD motif.

Prem L Sharma·Viktoria Nurpeisov·Raymond F Schinazi
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Abstract

The YXDD motif, where X is a variable amino acid, is highly conserved among various viral RNA-dependent DNA polymerases. Mutations in the YXDD motif can abolish enzymatic activity, alter the processivity and fidelity of enzymes and decrease virus infectivity. This review provides a summary of the significant documented studies on the YXDD motif of HIV-1, simian immunodeficiency virus, feline immunodeficiency virus and murine leukaemia virus and the impact of mutation that this motif has had on viral pathogenesis and drug treatment.

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Amino Acid MotifsConserved SequenceDrug ResistanceHumansRNA-Directed DNA PolymeraseRetroviridaeVirus ReplicationJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review

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Prem L Sharma, Viktoria Nurpeisov, Raymond F Schinazi. 2005. Retrovirus reverse transcriptases containing a modified YXDD motif.. https://doi.org/10.1177/095632020501600303

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