PubMed · 16007259
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Andrew E Czeizel. 2005-07-01. Birth defects are preventable.. https://doi.org/10.7150/ijms.2.91
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.