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PubMed · 16007693

Group-selective ring-closing enyne metathesis.

Sarah V Maifeld·Daesung Lee
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Abstract

The ring-closing metathesis (RCM) of dienynes represents a powerful methodology for the construction of mono- and bicyclic systems containing 1,3-diene functionality. Despite its synthetic potential, the utility of dienyne RCM is significantly reduced due to poor group selectivity. To circumvent this shortcoming, several strategies utilizing steric hindrance, electronic variation, relay metathesis and ring-closure kinetics have been implemented to exert control over the reaction pathways. This article highlights a variety of methods to achieve group-selective enyne RCM of dienynes.

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Bridged Bicyclo CompoundsElectrochemistryHydrocarbons, CyclicIndicators and ReagentsKineticsMolecular ConformationOrganic ChemicalsStereoisomerismJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Sarah V Maifeld, Daesung Lee. 2005-10-21. Group-selective ring-closing enyne metathesis.. https://doi.org/10.1002/chem.200500407

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