A likelihood approach for quantitative-trait-locus mapping with selected pedigrees.

K Wang

doi:10.1111/j.1541-0420.2005.031213.x

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PubMed · 16011693

A likelihood approach for quantitative-trait-locus mapping with selected pedigrees.

K Wang

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Abstract

Selective sampling is a cost-effective design for mapping quantitative trait loci (QTLs). A unified framework, which naturally combines two complementary sources of linkage information in the data, is proposed for the mapping of QTLs using selected pedigrees. Score statistics for detecting linkage are introduced for single-locus models (univariate or bivariate phenotypes) and two-locus epistasis models. A computer implementation of the methods for single-locus univariate-phenotype models is provided for nuclear families with arbitrary number of sibs and is freely available.

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Algorithms Chromosome Mapping Data Interpretation, Statistical Epistasis, Genetic Genetic Linkage Genetic Markers Genetic Vectors Humans Likelihood Functions Linkage Disequilibrium Lod Score Models, Genetic Models, Statistical Pedigree Phenotype Quantitative Trait Loci Quantitative Trait, Heritable Journal Article

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K Wang. 2005. A likelihood approach for quantitative-trait-locus mapping with selected pedigrees.. https://doi.org/10.1111/j.1541-0420.2005.031213.x

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