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PubMed · 16022774

SARS vaccine development.

Shibo Jiang·Yuxian He·Shuwen Liu
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Abstract

Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.

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EpitopesHumansMembrane GlycoproteinsSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory SyndromeSpike Glycoprotein, CoronavirusVaccines, InactivatedViral Envelope ProteinsViral VaccinesJournal ArticleReview

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Shibo Jiang, Yuxian He, Shuwen Liu. 2005. SARS vaccine development.. https://doi.org/10.3201/1107.050219

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