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Genomes optimize reproduction: aging as a consequence of the developmental program.

João Pedro de Magalhães·George M Church
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Abstract

Natural selection shapes genomes for reproduction, not for postreproductive survival. One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive deterioration of physiological function that we call aging are also discussed.

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Cellular SenescenceGene Expression Regulation, DevelopmentalGenomeHumansLongevityReproductionJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review

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João Pedro de Magalhães, George M Church. 2005. Genomes optimize reproduction: aging as a consequence of the developmental program.. https://doi.org/10.1152/physiol.00010.2005

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