A new folding paradigm for repeat proteins.

Tommi Kajander; Aitziber L Cortajarena; Ewan R G Main; Simon G J Mochrie; Lynne Regan

doi:10.1021/ja0524494

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A new folding paradigm for repeat proteins.

Tommi Kajander·Aitziber L Cortajarena·Ewan R G Main·Simon G J Mochrie·Lynne Regan

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Abstract

The folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.

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Amino Acid Motifs Models, Chemical Models, Molecular Protein Folding Protein Structure, Secondary Proteins Thermodynamics Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Tommi Kajander, Aitziber L Cortajarena, Ewan R G Main, Simon G J Mochrie, Lynne Regan. 2005-07-27. A new folding paradigm for repeat proteins.. https://doi.org/10.1021/ja0524494

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