Interleukin-13 (IL-13) pathway.

Ann Kelly-Welch; Erica M Hanson; Achsah D Keegan

doi:10.1126/stke.2932005cm8

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Interleukin-13 (IL-13) pathway.

Ann Kelly-Welch·Erica M Hanson·Achsah D Keegan

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Abstract

Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T(H)2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

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Animals Dimerization Humans Interleukin-13 Interleukin-13 Receptor alpha1 Subunit Models, Biological Protein-Tyrosine Kinases Receptors, Interleukin Receptors, Interleukin-13 Receptors, Interleukin-4 Signal Transduction Journal Article

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Ann Kelly-Welch, Erica M Hanson, Achsah D Keegan. 2005-07-19. Interleukin-13 (IL-13) pathway.. https://doi.org/10.1126/stke.2932005cm8

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