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Interleukin-4 (IL-4) pathway.

Ann Kelly-Welch·Erica M Hanson·Achsah D Keegan
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Abstract

Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

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AnimalsDimerizationHumansInterleukin-13 Receptor alpha1 SubunitInterleukin-4Models, BiologicalProtein-Tyrosine KinasesReceptors, InterleukinReceptors, Interleukin-13Receptors, Interleukin-4Signal TransductionTh2 CellsJournal Article

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Ann Kelly-Welch, Erica M Hanson, Achsah D Keegan. 2005-07-19. Interleukin-4 (IL-4) pathway.. https://doi.org/10.1126/stke.2932005cm9

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