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A model for Rab GTPase localization.

S Pfeffer
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Abstract

The human genome encodes almost 70 Rab GTPases. These proteins are C-terminally geranylgeranylated and are localized to the surfaces of distinct membrane-bound compartments in eukaryotic cells. This mini review presents a working model for how Rabs achieve and maintain their steady-state localizations. Data from a number of laboratories suggest that Rabs participate in the generation of macromolecular assemblies that generate functional microdomains within a given membrane compartment. Our data suggest that these complex interactions are important for the cellular localization of Rab proteins at steady state.

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AnimalsGenome, HumanHumansMammalsModels, Biologicalrab GTP-Binding ProteinsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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S Pfeffer. 2005. A model for Rab GTPase localization.. https://doi.org/10.1042/bst0330627

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