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PubMed · 16048248

Transforming growth factor-beta: importance in long-term peritoneal membrane changes.

Peter J Margetts·Kook-Hwan Oh·Martin Kolb
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Abstract

We have provided evidence from adenovirus-mediated gene transfer to the peritoneum that transforming growth factor-beta1 mimics many of the functional and structural changes in the peritoneum in patients on long-term peritoneal dialysis, including fibrosis, increased submesothelial thickness, angiogenesis, increased solute transport, and ultrafiltration dysfunction. We review several key properties of this important fibrogenic molecule.

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HumansPeritoneal DiseasesPeritoneumTransforming Growth Factor betaTransforming Growth Factor beta1Journal ArticleResearch Support, Non-U.S. Gov'tReview

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Peter J Margetts, Kook-Hwan Oh, Martin Kolb. 2005. Transforming growth factor-beta: importance in long-term peritoneal membrane changes.. https://pubmed.ncbi.nlm.nih.gov/16048248/

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