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Serine proteases and cardiac function.

Qingyu Wu·Hai-Chien Kuo·Gary Gang Deng
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Abstract

The serine proteases of the trypsin superfamily are versatile enzymes involved in a variety of biological processes. In the cardiovascular system, the importance of these enzymes in blood coagulation, platelet activation, fibrinolysis, and thrombosis has been well established. Recent studies have shown that trypin-like serine proteases are also important in maintaining cardiac function and contribute to heart-related disease processes. In this review, we describe the biological function of corin, tissue kallikrein, chymase and urokinase and discuss their roles in cardiovascular diseases such as hypertension, cardiac hypertrophy, heart failure, and aneurysm.

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AnimalsAortic Aneurysm, AbdominalAtrial Natriuretic FactorCardiomegalyChymasesHeartHumansHypertensionHypertension, PulmonaryMyocardial IschemiaSerine EndopeptidasesTissue KallikreinsUrokinase-Type Plasminogen ActivatorJournal ArticleReview

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BibTeXRIS

Qingyu Wu, Hai-Chien Kuo, Gary Gang Deng. 2005-08-01. Serine proteases and cardiac function.. https://doi.org/10.1016/j.bbapap.2004.09.005

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