B cell development and receptor diversity during aging.

David Allman; Juli P Miller

doi:10.1016/j.coi.2005.07.002

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B cell development and receptor diversity during aging.

David Allman·Juli P Miller

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Abstract

Although it is clear that B cell genesis declines with age, the specifics of why this happens are largely unknown. Even less clear is how the age-related decline in B cell development might affect peripheral B cell function. Recent studies have investigated the impact of aging on both B cell genesis in the bone marrow and the resulting peripheral B cell repertoire. On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function.

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Aging Animals B-Lymphocytes Humans Models, Immunological Stem Cells Journal Article Research Support, Non-U.S. Gov't Review

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David Allman, Juli P Miller. 2005. B cell development and receptor diversity during aging.. https://doi.org/10.1016/j.coi.2005.07.002

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