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Clonal evolution in primary 5q-syndrome.

K F Wong·J K Chan·Y C Chu·Y L Kwong
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Abstract

Primary 5q-syndrome is a type of myelodysplastic syndrome characterized by refractory anemia, thrombocytosis, and hypolobulated megakaryocytes. The risk of leukemic transformation is low. A case of 5q- syndrome that occurred in a 42-year-old woman and was complicated by leukemic transformation 7 years after the initial diagnosis is reported. An additional clonal karyotypic anomaly, del(7q), was seen in the leukemic cells. The literature on leukemic and karyotypic evolution of primary 5q- syndrome is reviewed and the implication of karyotypic evolution is discussed.

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Acute DiseaseAdultAgedAged, 80 and overCell Transformation, NeoplasticChromosome AberrationsFemaleHumansKaryotypingLeukemiaMaleMiddle AgedMyelodysplastic SyndromesCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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K F Wong, J K Chan, Y C Chu, Y L Kwong. 1992-07-01. Clonal evolution in primary 5q-syndrome.. https://doi.org/10.1002/1097-0142(19920701)70%3A1%3C100%3A%3Aaid-cncr2820700116%3E3.0.co%3B2-f

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