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AAA+ proteins: have engine, will work.

Phyllis I Hanson·Sidney W Whiteheart
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Abstract

The AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.

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Adenosine TriphosphatasesAnimalsCatalysisConserved SequenceCrystallography, X-RayDNA ReplicationHumansModels, MolecularProtein ConformationSubstrate SpecificityJournal ArticleReview

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Phyllis I Hanson, Sidney W Whiteheart. 2005. AAA+ proteins: have engine, will work.. https://doi.org/10.1038/nrm1684

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