Encoded combinatorial chemistry.

S Brenner; R A Lerner

doi:10.1073/pnas.89.12.5381

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Encoded combinatorial chemistry.

S Brenner·R A Lerner

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Abstract

The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences. After the chemical entity is bound to a target, the genetic tag can be amplified by replication and utilized for enrichment of the bound molecules by serial hybridization to a subset of the library. The nature of the chemical structure bound to the receptor is decoded by sequencing the nucleotide tag.

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S Brenner, R A Lerner. 1992-06-15. Encoded combinatorial chemistry.. https://doi.org/10.1073/pnas.89.12.5381

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