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PubMed · 16091411

ProRule: a new database containing functional and structural information on PROSITE profiles.

Christian J A Sigrist·Edouard De Castro·Petra S Langendijk-Genevaux·Virginie Le Saux·Amos Bairoch·Nicolas Hulo
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Abstract

MOTIVATION: Increase the discriminatory power of PROSITE profiles to facilitate function determination and provide biologically relevant information about domains detected by profiles for the annotation of proteins. SUMMARY: We have created a new database, ProRule, which contains additional information about PROSITE profiles. ProRule contains notably the position of structurally and/or functionally critical amino acids, as well as the condition they must fulfill to play their biological role. These supplementary data should help function determination and annotation of the UniProt Swiss-Prot knowledgebase. ProRule also contains information about the domain detected by the profile in the Swiss-Prot line format. Hence, ProRule can be used to make Swiss-Prot annotation more homogeneous and consistent. The format of ProRule can be extended to provide information about combination of domains. AVAILABILITY: ProRule can be accessed through ScanProsite at http://www.expasy.org/tools/scanprosite. A file containing the rules will be made available under the PROSITE copyright conditions on our ftp site (ftp://www.expasy.org/databases/prosite/) by the next PROSITE release.

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Amino Acid SequenceDatabase Management SystemsDatabases, ProteinInformation Storage and RetrievalMolecular Sequence DataProtein ConformationProteinsSequence Analysis, ProteinStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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Christian J A Sigrist, Edouard De Castro, Petra S Langendijk-Genevaux, Virginie Le Saux, Amos Bairoch, Nicolas Hulo. 2005-08-09. ProRule: a new database containing functional and structural information on PROSITE profiles.. https://doi.org/10.1093/bioinformatics%2Fbti614

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