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Interstitial Doppler optical coherence tomography.

Victor X D Yang·You X Mao·Nigel Munce·Beau Standish·Walter Kucharczyk·Norman E Marcon·Brian C Wilson·I Alex Vitkin
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Abstract

Doppler optical coherence tomography (OCT) can image tissue structure and blood flow at micrometer-scale resolution but has limited imaging depth. We report a novel, linear-scanning, needle-based Doppler OCT system using angle-polished gradient-index or ball-lensed fibers. A prototype system with a 19-guage (diameter of approximately 0.9 mm) echogenic needle is constructed and demonstrates in vivo imaging of bidirectional blood flow in rat leg and abdominal cavity. To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation.

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AnimalsBlood Flow VelocityEchocardiography, DopplerEquipment DesignEquipment Failure AnalysisFeasibility StudiesImage EnhancementMicrocirculationRatsTomography, Optical CoherenceUltrasonography, InterventionalJournal ArticleResearch Support, Non-U.S. Gov't

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Victor X D Yang, You X Mao, Nigel Munce, Beau Standish, Walter Kucharczyk, Norman E Marcon, Brian C Wilson, I Alex Vitkin. 2005-07-15. Interstitial Doppler optical coherence tomography.. https://doi.org/10.1364/ol.30.001791

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