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Chromophoric binaphthyl derivatives.

Tomás Bríza·Zdenĕk Kejík·Petr Vasek·Jarmila Králová·Pavel Martásek·Ivana Císarová·Vladimír Král
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Abstract

A short synthetic route is outlined, starting from bromo-BN derivatives, via halogen lithium exchange, subsequent Michael reaction with dimethylaminoacrolein, hydrolysis to the corresponding aldehyde, and final condensation with a benzothiazolium unit to produce a BN-pentamethinium system, which absorbs in the visible range around 450 nm. Enantiopure ligands show a decent Cotton effect in the CD spectrum. Preliminary data show potential of these compounds in the area of supramolecular chemistry (enantioselective recognition) and also for medicinal application (induction of apoptosis). [reaction: see text]

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ApoptosisCatalysisCircular DichroismHydrocarbons, BrominatedMolecular StructureNaphthalenesStereoisomerismJournal ArticleResearch Support, Non-U.S. Gov't

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Tomás Bríza, Zdenĕk Kejík, Petr Vasek, Jarmila Králová, Pavel Martásek, Ivana Císarová, Vladimír Král. 2005-08-18. Chromophoric binaphthyl derivatives.. https://doi.org/10.1021/ol051139n

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