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Diversification of CDK11 transcripts during chicken testis development and regression.

Victor P Francone·Jovita Mezquita
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Abstract

CDK11 (cyclin-dependent kinase 11, formerly known as PITSLRE) is a serine/threonine kinase that associates with the cyclin L2 regulatory partner. CDK11 catalytic activity has been associated with apoptosis, transcription, and RNA processing. Here, we identify novel chicken testis CDK11 transcripts that differ in their 5'UTR, 3'UTR, splicing of the exon 6, and polyadenylation. We have also characterized the differential expression of CDK11 in somatic tissues, during testis development and upon testicular regression by diethylstilbestrol (DES) treatment. The heterogeneity of CDK11 transcripts presented in this study suggests new possibilities for post-transcriptional regulation.

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AnimalsBase PairingBase SequenceBlotting, NorthernChickensCyclin-Dependent KinasesDNA PrimersDNA, ComplementaryDiethylstilbestrolGene Expression Regulation, EnzymologicGenetic VariationMaleMolecular Sequence DataNucleic Acid Amplification TechniquesRNA, MessengerReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNATestisComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Victor P Francone, Jovita Mezquita. 2005. Diversification of CDK11 transcripts during chicken testis development and regression.. https://doi.org/10.1002/mrd.20355

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