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Longitudinal study to explore chronic neuropsychologic effects on solvent exposed workers.

Andreas Ihrig·Michael C Dietz·Michael Bader·Gerhard Triebig
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Abstract

AIM: The aim of the study was to examine possible neurotoxic effects on the central nervous system (CNS) in relation to a chronic solvent exposure at the workplace. METHOD: The collective included 127 workers exposed to solvent mixtures, such as spray painters and printers. They were examined twice by means of a physical examination, neuropsychological testbattery, biological and air monitoring. RESULTS: Major component of the solvents were white spirits in concentrations up to 127 ppm in air and 2,666 microg/l in blood. Single substances were mainly toluene and xylenes in concentrations below current threshold values at the workplace. During the 2 yr interval, the concentrations of solvents decreased, and no significant associations between the neuropsychological tests and the solvent exposure were found. Regarding the whole working history of each participant, we found a significant reduction on information processing velocity and performance in the trailmaking test, as well as more complaints of workers with higher solvent exposure in the past. CONCLUSIONS: A slight increase of subjective complaints and a deteriorated power of concentration seems to be associated with chronic solvent exposure.

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AdultCentral Nervous SystemFollow-Up StudiesGermanyHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsNeurotoxinsOccupational ExposureSolventsJournal ArticleResearch Support, Non-U.S. Gov't

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Andreas Ihrig, Michael C Dietz, Michael Bader, Gerhard Triebig. 2005. Longitudinal study to explore chronic neuropsychologic effects on solvent exposed workers.. https://doi.org/10.2486/indhealth.43.588

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