Angiogenesis: update 2005.

H F Dvorak

doi:10.1111/j.1538-7836.2005.01361.x

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PubMed · 16102050

Angiogenesis: update 2005.

H F Dvorak

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Abstract

Angiogenesis has critical roles in normal vascular development and in important pathologies including cancer, wound healing and inflammation. This brief article will review the angiogenic response induced by the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) family of proteins and particularly VEGF-A, thought to be the single most important angiogenic factor. It will also review the steps and mechanisms by which VEGF-A induces the formation of new blood vessels and will provide an initial classification of the abnormal blood vessels that form in pathological angiogenesis. Finally, it will touch on the exciting relationships that are emerging between angiogenesis and the hemostatic and nervous systems.

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Animals Blood Coagulation Cell Proliferation Endothelial Growth Factors Humans Models, Biological Neovascularization, Pathologic Neovascularization, Physiologic Signal Transduction Vascular Endothelial Growth Factor A Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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H F Dvorak. 2005. Angiogenesis: update 2005.. https://doi.org/10.1111/j.1538-7836.2005.01361.x

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