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PubMed · 16106902

[Posttraumatic stress disorder (PTSD)].

Ferenc Martényi
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Abstract

The diagnosis of posttraumatic stress disorder (PTSD) has been introduced in 1980. The diagnosis, as construct raises several political, moral, legal, and compensation issues. PTSD is considered as a multisystemic dysregulation, involving the hypothalamic- pituitary - adrenal axis, adrenergic hypersensibility, and serotonergic dysfunction. The prevalence of PTSD is 1-9% in the general population, but substantially higher among victims of traumatic events: 19-70%. Placebo controlled studies provide a body of evidence concerning efficacy of selective serotonin reuptake inhibitors in the treatment of PTSD both in the acute and maintenance treatments. Studies with balanced male-female ratio suggest no gender-related differences in the clinical response, furthermore both civilians and veterans improved significantly for selective serotonin reuptake inhibitor treatment.

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Antidepressive Agents, Second-GenerationCatecholaminesComorbidityControlled Clinical Trials as TopicCrime VictimsFemaleHumansHypothalamo-Hypophyseal SystemIncidenceLife Change EventsMaleParoxetinePituitary-Adrenal SystemPrevalenceSelective Serotonin Reuptake InhibitorsSertralineSeverity of Illness IndexStress Disorders, Post-TraumaticTreatment OutcomeVeterans Disability ClaimsVietnam ConflictWorld War IWorld War IIEnglish AbstractJournal ArticleReview

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Ferenc Martényi. 2004-11-14. [Posttraumatic stress disorder (PTSD)].. https://pubmed.ncbi.nlm.nih.gov/16106902/

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