Morphogens as growth cone signalling molecules.

Cristina Sánchez-Camacho; Josana Rodríguez; José María Ruiz; Françoise Trousse; Paola Bovolenta

doi:10.1016/j.brainresrev.2004.10.004

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PubMed · 16111553

Morphogens as growth cone signalling molecules.

Cristina Sánchez-Camacho·Josana Rodríguez·José María Ruiz·Françoise Trousse·Paola Bovolenta

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Abstract

Morphogen signalling among cells is one of the most important mechanisms underlying the progressive patterning of embryos. Members of the hedgehog (Hh), wingless (Wnt), transforming growth factor-beta (TGFbeta), and fibroblast growth factor (Fgf) families of extracellular signalling molecules act as morphogens. Recent studies have demonstrated that members of these four families of proteins, secreted by well-characterised organiser centres in the central nervous system (CNS) as floor plate or midbrain-hindbrain boundary, are reused at later developmental stages to control axon growth. Here, we have summarised the evidence for this novel idea with a particular emphasis on those related to Shh and Wnt signalling-the object of some works in our laboratory.

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Animals Body Patterning Bone Morphogenetic Proteins Central Nervous System Fibroblast Growth Factors Gene Expression Regulation, Developmental Growth Cones Hedgehog Proteins Intercellular Signaling Peptides and Proteins Models, Biological Morphogenesis Neurons Signal Transduction Trans-Activators Wnt Proteins Journal Article Research Support, Non-U.S. Gov't Review

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Cristina Sánchez-Camacho, Josana Rodríguez, José María Ruiz, Françoise Trousse, Paola Bovolenta. 2004-12-24. Morphogens as growth cone signalling molecules.. https://doi.org/10.1016/j.brainresrev.2004.10.004

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