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PubMed · 16112854

Sample flow switching techniques on microfluidic chips.

Yu-Jen Pan·Jin-Jie Lin·Win-Jet Luo·Ruey-Jen Yang
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Abstract

This paper presents an experimental investigation into electrokinetically focused flow injection for bio-analytical applications. A novel microfluidic device for microfluidic sample handling is presented. The microfluidic chip is fabricated on glass substrates using conventional photolithographic and chemical etching processes and is bonded using a high-temperature fusion method. The proposed valve-less device is capable not only of directing a single sample flow to a specified output port, but also of driving multiple samples to separate outlet channels or even to a single outlet to facilitate sample mixing. The experimental results confirm that the sample flow can be electrokinetically pre-focused into a narrow stream and guided to the desired outlet port by means of a simple control voltage model. The microchip presented within this paper has considerable potential for use in a variety of applications, including high-throughput chemical analysis, cell fusion, fraction collection, sample mixing, and many other applications within the micro-total-analysis systems field.

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Biosensing TechniquesElectrochemistryEquipment DesignEquipment Failure AnalysisFlow Injection AnalysisMicrofluidic Analytical TechniquesEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Yu-Jen Pan, Jin-Jie Lin, Win-Jet Luo, Ruey-Jen Yang. 2005-08-19. Sample flow switching techniques on microfluidic chips.. https://doi.org/10.1016/j.bios.2005.07.013

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