PubMed · 16115765
Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.
Abstract
We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor delta (PPARdelta) based on a lead structure from our PPARalpha program. Compound 33 showed good pharmacokinetics.
Explore related subjects
Keep this discovery
Explore connections, maps & timelines
Stefan Weigand, Hilmar Bischoff, Elke Dittrich-Wengenroth, Heike Heckroth, Dieter Lang, Andrea Vaupel, Michael Woltering. 2005-10-15. Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.. https://doi.org/10.1016/j.bmcl.2005.06.023
Cite the original work for its findings. Save a collection to share your selection of sources.