Combining electron microscopy and comparative protein structure modeling.

Maya Topf; Andrej Sali

doi:10.1016/j.sbi.2005.08.001

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Combining electron microscopy and comparative protein structure modeling.

Maya Topf·Andrej Sali

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Abstract

Recently, advances have been made in methods and applications that integrate electron microscopy density maps and comparative modeling to produce atomic structures of macromolecular assemblies. Electron microscopy can benefit from comparative modeling through the fitting of comparative models into electron microscopy density maps. Also, comparative modeling can benefit from electron microscopy through the use of intermediate-resolution density maps in fold recognition, template selection and sequence-structure alignment.

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Cryoelectron Microscopy Crystallography, X-Ray Models, Molecular Protein Conformation Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Maya Topf, Andrej Sali. 2005. Combining electron microscopy and comparative protein structure modeling.. https://doi.org/10.1016/j.sbi.2005.08.001

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