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Downhill protein folding: evolution meets physics.

Martin Gruebele
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Abstract

Proteins can be redesigned to fold downhill on a free energy surface characterized by only a few coordinates, confirming a principal prediction of the 'energy-landscape' model. Nonetheless, natural proteins have small but significant barriers. Spectroscopy and kinetics reveal potential biological causes for activation barriers during protein folding: evolution against protein aggregation and for protein function.

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AnimalsEnvironmentEvolution, MolecularGenetic CodeProtein FoldingProteinsThermodynamicsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Review

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Martin Gruebele. 2005-04-01. Downhill protein folding: evolution meets physics.. https://doi.org/10.1016/j.crvi.2005.02.007

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