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PubMed · 16130096

Autism severity and temporal lobe functional abnormalities.

Isabelle Gendry Meresse·Mônica Zilbovicius·Nathalie Boddaert·Laurence Robel·Anne Philippe·Ignacio Sfaello·Laurence Laurier·Francis Brunelle·Yves Samson·Marie-Christine Mouren·Nadia Chabane
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Abstract

Two independent studies have described bilateral temporal hypoperfusion in autistic children. Temporal regions are implicated in social perception, language, and "theory-of-mind," abilities that are impaired in autism. We investigated a putative relationship between cerebral blood flow (rCBF) measured at rest and clinical profile of 45 autistic children (Autism Diagnostic Interview-Revised [ADI-R] scores). A whole-brain covariance analysis was performed. Significant negative correlation was observed between rCBF and ADI-R score in the left superior temporal gyrus. The more severe the autistic syndrome, the more rCBF is low in this region, suggesting that left superior temporal hypoperfusion is related to autistic behavior severity.

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Autistic DisorderCerebrovascular CirculationChildChild, PreschoolFemaleFunctional LateralityHumansMalePositron-Emission TomographySeverity of Illness IndexTemporal LobeComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Isabelle Gendry Meresse, Mônica Zilbovicius, Nathalie Boddaert, Laurence Robel, Anne Philippe, Ignacio Sfaello, Laurence Laurier, Francis Brunelle, Yves Samson, Marie-Christine Mouren, Nadia Chabane. 2005. Autism severity and temporal lobe functional abnormalities.. https://doi.org/10.1002/ana.20597

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