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Negative correlation between compositional symmetries and local recombination rates.

Liang Chen·Hongyu Zhao
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Abstract

Although still not much understood, the universal reverse complement symmetry in genomes may contain much information about the genome. In this article, under the hypothesis that recombination rate variations may be related to the high order DNA structure, we studied the association between local recombination rates and local symmetry levels in mouse, rat and human. We found significant negative correlations between recombination rates and reverse complement compositional symmetries in these three organisms. This negative correlation pattern also held at individual chromosome levels when data only from each individual chromosome was analyzed.

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AnimalsBase CompositionBase SequenceChromosome MappingComputer SimulationGenetic VariationGenome, HumanHumansMiceModels, GeneticModels, StatisticalMolecular Sequence DataPolymorphism, Single NucleotideRatsRecombination, GeneticSequence Analysis, DNASpecies SpecificityStatistics as TopicComparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.

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Liang Chen, Hongyu Zhao. 2005-08-30. Negative correlation between compositional symmetries and local recombination rates.. https://doi.org/10.1093/bioinformatics%2Fbti651

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