Mitochondrial regulation of oxygen sensing.

Eric L Bell; Brooke M Emerling; Navdeep S Chandel

doi:10.1016/j.mito.2005.06.005

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Mitochondrial regulation of oxygen sensing.

Eric L Bell·Brooke M Emerling·Navdeep S Chandel

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Abstract

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

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Animals Electron Transport Gene Expression Regulation Homeostasis Humans Hypoxia Hypoxia-Inducible Factor 1 Mitochondria Models, Biological Neovascularization, Pathologic Oxygen Reactive Oxygen Species Signal Transduction Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Eric L Bell, Brooke M Emerling, Navdeep S Chandel. 2005. Mitochondrial regulation of oxygen sensing.. https://doi.org/10.1016/j.mito.2005.06.005

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